- Title
- Dynamic control of the bronchial circulation in the conscious dog: preliminary data on the role of alpha and beta adrenoceptors, and of cholinoceptors
- Creator
- van der Touw, T. J.; White, Saxon William; Hennessy, E. J.; Porges, W. L.; Quail, A. W.; Glenfield, P. J.
- Relation
- 5th Australian and New Zealand Symposium on the Microcirculation . Progress in microcirculation research: proceedings of the fifth Australian and New Zealand Symposium (Canberra 10-12 February, 1989) p. 54-56
- Publisher
- Australian and New Zealand Microcirculation Society
- Resource Type
- conference paper
- Date
- 1989
- Description
- Due to a unique vascular network, bronchial blood flow may be determined by the opening of anastomotic channels during perfusion pressure changes as well as by neurohumoral mechanisms. For example, previous studies from this laboratory have shown that a rise in aortic pressure, or a sigh followed by apnoea, result in dramatic rises (< 1s time-constant) in bronchial flow and conductance, which are not diminished by conventional autonomic blockade. These data suggest that unusual mechanical effects may indeed be involved, or that unknown reflex pathways are active. In order to define further the potential neurohumoral factors regulating bronchial flow, the present studies were designed to examine the role of a- and a-adrenoceptor, and cholinoceptor control. While the presence of such receptor mechanisms in the bronchial bed are likely the data were derived from indirect techniques for estimating airway vascular activity in anaesthetized, open-chested dogs. By contrast, in this study the continuous-wave Doppler flowmeter was used to examine the dynamic effects of these receptor control systems on bronchial flow in the conscious dog.
- Subject
- bronchial circulation; adrenoceptors; cholinoceptors
- Identifier
- http://hdl.handle.net/1959.13/939165
- Identifier
- uon:12747
- Identifier
- ISBN:0858238322
- Language
- eng
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